Buy Cheap Pick A Best Cheap For Sale HORNCHURCH CHELSEA Classic ankle boots stone Low Cost Largest Supplier Cheap Sale How Much lKlmg

SKU41280355
Buy Cheap Pick A Best Cheap For Sale HORNCHURCH CHELSEA - Classic ankle boots - stone Low Cost Largest Supplier Cheap Sale How Much lKlmg
HORNCHURCH CHELSEA - Classic ankle boots - stone
The Standard
Login
Individual Order Form
Achtung
This tooltip is visible by default because it has "is_expanded" class. Outlet Hot Sale Really Cheap Price Under Armour UA Spotlight FG Clearance Footlocker Pictures Online Shop n1Ku3181jZ
Achtung
This tooltip is visible by default because it has "is_expanded" class. Givenchy Urban Street hitop sneakers Black Cheap With Credit Card Authentic Online New Arrival bkrBlfW7Hl
Doucals Mike textured leather loafers In China Sale Online 7IYOMe4m9u

Sie haben keine Produkte im Warenkorb.

Prada Graphic lowtop sneakers White Cool Shopping Sale Fashion Style V23Uw4j9D

Les contenus ne sont pas tous disponibles dans la langue choisie. Désirez-vous découvrir le monde de la Rhätische Bahn dans son ensemble? Crime London Raw lowtop sneakers Black 100% Guaranteed Cheap Online sRxVar

Achtung
This tooltip is visible by default because it has "is_expanded" class. adidas Daily 20 Denim Sneaker Official Site Outlet Get Authentic 4UGmk
Achtung
This tooltip is visible by default because it has "is_expanded" class. and this is a link
Close Navigation
Outlet Pay With Paypal REVOLUTION 4 EU Neutral running shoes black/black Prices Cheap Price Outlet Online Shop Best Sale Cheap Online Discount Codes Really Cheap tzzADc2STx
C Diem rearzip boots Black Pay With Paypal Cheap Price Discount Low Price ndJ5LqeOg
Search Menu

Les contenus ne sont pas tous disponibles dans la langue choisie. Désirez-vous découvrir le monde de la Rhätische Bahn dans son ensemble? anglais

Darauf legen wir den Fokus

In einem ersten Schritt legt die Rhätische Bahn den Fokus auf die zwei Handlungsfelder «Betriebliches Gesundheitsmanagement» und «Energiesparen». Dadurch soll die Gesundheit der Mitarbeitenden gestärkt sowie die Energieeffizienz gesteigert werden. Projekte und Kampagnen in diesen beiden Handlungsfeldern werden gezielt gefördert und begleitet. Die Entwicklung der übrigen Handlungsfelder wird überwacht, um bei Veränderungen rasch reagieren zu können.

Handlungsfelder der Rhätischen Bahn mit den zwei Fokusthemen «Energiesparen» und «Betriebliches Gesundheitsmanagement».

Im Bereich Energie kann die Rhätische Bahn den grössten Effekt erzielen, da der Energiebedarf sehr gross ist und aufgrund der zunehmenden Zugkilometer sowie der Ausstattung der Züge weiter steigt. Die Energieeffizienz zu steigern ist Teil der Strategie 2020. Massnahmen wie die Automatisierung der Weichenheizungen, die Optimierung von Gebäudeheizungen oder Energiesparmassnahmen an Fahrzeugen sollen dazu führen, dass der gesamte Energiebedarf der Rhätischen Bahn trotz zunehmenden Zugskilometern und höheren Komfortausrüstungen in den Zügen unterproportional ansteigt. Nebst der Steigerung der Energieeffizienz steht die Nutzung erneuerbarer Energie im Vordergrund. Dementsprechend bezieht die Rhätische Bahn den gesamten Strom für ihre Immobilien sowie die elektrisch betriebenen Triebfahrzeuge vollständig aus Wasserkraft.

Die Rhätische Bahn will die Gesundheit der Mitarbeitenden erhalten und stärken. Gesundheit ist nicht nur für jeden einzelnen Mitarbeitenden wichtig. Sie bildet zusammen mit anderen Faktoren auch die Grundlage für die Qualität der Arbeit und damit für den Erfolg des Unternehmens. Um alle gesundheitsrelevanten Aktivitäten, Strukturen und Prozesse zu koordinieren, wurden diese im «Betrieblichen Gesundheitsmanagement (BGM)» zusammengefasst. Arbeitssicherheit und der Eingliederungsprozess von verunfallten oder erkrankten Mitarbeitenden sind ebenso Bestandteile des BGM wie die Betriebliche Gesundheitsförderung.

Cela pourrait aussi vous intéresser

Kennzahlen

Find out more

Skip to Main Content

Home

Events

Community

Multimedia

Portals

Special Editions

Research Journals

Reviews Journals:Trends In...

Partner Journals

Information

Marketplace Recommendations
Cancer Immunotherapy Strategies Poster
Request a Cancer Immunotherapy Strategies Poster for your lab. – Bio-Techne
Adoptive Cell Transfer Research
Find products to analyze CAR signaling, expand cells, verify T-cell function, and more.
MAPK Signaling Pathway
A group of serine/threonine kinases that mediate intracellular signaling. Learn more. – Biorbyt
Plant Tissue Culture Products
Explore our non-animal culture products. Antibiotics, gelling agents, cytokinins and more.
Ads Powered with

Access provided by

< Previous Article
Next Article >
Volume 19, Issue 13 , p1123–1127, 14 July 2009
Report
Sale New Arrival HAGERMAN Laceup boots brown For Nice Sale Online Looking For Buy Cheap Many Kinds Of Outlet Inexpensive SXvC8e
Switch to Enhanced View
Emma Louise Stone
Converse Ox Jute America Chuck Taylor All Stars Jute/Navy Clearance Manchester 7VTDuyV

Affiliations

Correspondence

Emma Louise Stone
Search for articles by this author

Affiliations

Correspondence

Gareth Jones
Cheap Sale Best Sale ELLINGTON Trainers black Pictures Sale Online Free Shipping Collections Shopping Online dGwnf

Affiliations

Correspondence

Gareth Jones
Clearance Wholesale Price From China Soludos Frenchie Smoking Slippers Ocean Blue Sale Buy Nicekicks 5p59c9

Affiliations

Correspondence

Stephen Harris
Search for articles by this author

Affiliations

Published Online: June 18, 2009
Published online: June 18, 2009
Captures
Mentions
Social Media
Citations
DOI: https://doi.org/10.1016/j.cub.2009.05.058
Publication History
Published online: June 18, 2009 Accepted: May 8, 2009 ; Received in revised form: May 5, 2009 ; Received: April 6, 2009 ;
User License
Figure 1

miR-122 levels are decreased in mice and patients with HH. () qPCR analysis of miR-122 expression in liver total RNA of WT ( = 8) and ( = 11) mice ( = 0.039). mmu-miR-122, miR-122 stem-loop. () Analysis of miR-122 expression in the liver of WT mice injected with dextran (Dxt; = 5) and iron-dextran (Fe; = 6) ( = 0.187) and () WT mice on a regular ( = 4) or iron-supplemented diet (dFe; = 4) ( = 0.471). () miR-122 levels were reduced in liver biopsies of HH patients ( = 6) compared with the control group without iron overload (Ctr; = 4) ( = 0.068). hsa-miR-122, miR-122 stem-loop. Data were normalized to the appropriate reference genes: miR-194 ( and ), mouse RNU6 (), and human RNU6 (). Data are mean ± SD, and values from WT mouse (–) and control patient () groups were set to 100%. * < 0.05, 2-tailed Student’s test.

Efficient and specific antagonism of miR-122 in murine liver. To functionally investigate a possible link between miR-122 and iron metabolism, we inhibited miR-122 by a single i.p. injection of locked nucleic acid–modified (LNA-modified) anti-miR oligonucleotides ( Thom Browne OffWhite Suede Tricolor Stripe Sneakers Buy Cheap Countdown Package Clearance Hot Sale Buy Cheap With Mastercard dvS7mTw
) into age- and sex-matched C57BL/6 WT mice. To inhibit miR-122 specifically, we injected an anti-miR compound with perfect complementarity to miR-122 (perfect match; referred to herein as PM_anti–miR-122). As negative controls, mice were injected either with an LNA control compound with 2 mismatches (referred to herein as 2MM_antimiR-122) or saline vehicle control (0.9% NaCl). Mice were sacrificed 3 and 6 weeks after injection. Independent of treatment, mice were viable and exhibited no overt physical or behavioral abnormalities. To assess the efficiency of miR-122 inhibition, hepatic miR-122 levels were measured by qPCR (Figure 2 A). The amount of detectable miR-122 was reduced compared with saline-injected mice by 28- and 11-fold at 3 and 6 weeks, respectively, after injection with PM_anti–miR-122. Injection of the 2MM_anti–miR-122 control did not significantly reduce miR-122 detectability. Expression of the miR-122 primary transcript was not altered under the experimental conditions (Supplemental Figure 1A). To exclude that PM_anti–miR-122 administration disturbs the expression of other miRNAs we analyzed miRNA expression profiles in the livers, hearts and spleens of the same mice (Supplemental Figure 2). Our data show specific and exclusive inhibition of miR-122 in the liver of PM_anti–miR-122 treated mice. In the spleen, expression of 3 miRNAs was increased in PM_anti–miR-122–treated mice, which may be a consequence of increased extramedullary hematopoiesis (see below). Alteration of the miRNA profile was not detected in the heart, where miR-122 is not expressed ( 26 ).

Figure 2

miR-122 depletion is functional. () miR-122 detectability was decreased in the liver of PM_anti–miR-122–injected mice. Mice were injected i.p. with a single dose of 25 μg/g PM_anti–miR-122 (PM), 2MM_anti–miR-122 (2MM), or saline (SAL) and sacrificed 3 or 6 weeks after injection. Hepatic miR-122 expression was analyzed by qPCR, and data were normalized to the expression of small nucleolar RNA Sno135. Detectability of miR-122 was reduced 3 ( = 0.0001) and 6 ( = 0.0001) weeks after PM_anti–miR-122 administration. () was increased in the liver of PM_anti–miR-122–injected mice 3 ( = 0.0001) and 6 ( = 0.0001) weeks after treatment. Values were normalized to mRNA expression of reference gene . Data are mean ± SD ( = 8), and the saline-treated group was set to 100%. ** < 0.01, 1-way ANOVA.

Furthermore, miR-122 inhibition by PM_anti–miR-122 increased hepatic mRNA levels of the miR-122 target gene aldolase A ( Aldoa ; ref. Wolverine Loader 8 Steel Toe Boot Brown Mens Work Boots Outlet Really OKrAXSO06
) at both 3 weeks (2.8-fold vs. saline; 4.0-fold vs. 2MM_anti–miR-122) and 6 weeks after treatment (3.4-fold vs. saline; 2.7-fold vs. 2MM_anti–miR-122; Figure 2 B). Likewise, serum cholesterol levels were decreased ( Cheap Price Fake Cheap Sale Visit Premiata Sneakers for Men On Sale Medium Grey Suede leather 2017 10 8 Geniue Stockist Online Outlet Order Online Y9c0EX
, 31 ) 3 weeks after injection of PM_anti–miR-122 (Supplemental Figure 1B). Taken together, these data suggest that PM_anti–miR-122 injection specifically and efficiently antagonizes miR-122 and that miR-122 inhibition is functional.

Be the first to save!

Privacy Policy
Stay Connected
TRIACTIVE RUN Trainers white Clearance Wholesale Price 80RlnmsmQI
MoneyCenter 2018 New Sale Online For Sale Cheap Authentic Alexander McQueen derby shoes Black Clearance Sale Cheap Sale Discounts k5JH6C
Donald J Pliner Hanley Cheap Shop Offer f3yuubv2
Terms of Use
© Wal-Mart Stores, Inc.
Ref: To ensure we are able to help you as best we can, please include your reference number: BPT5HIXSU5