Websites Cheap Price Cinzia Araia hitop sneakers Black Shopping Online High Quality Top Quality Cheap Online Pxm0s

SKU93751814
Websites Cheap Price Cinzia Araia hi-top sneakers - Black Shopping Online High Quality Top Quality Cheap Online Pxm0s
Cinzia Araia hi-top sneakers - Black
The Standard
Login
Individual Order Form
Achtung
This tooltip is visible by default because it has "is_expanded" class. Atlantic Stars ANTARES SUEDE amp; NYLON RUNNING SNEAKERS Order Shopping Original X5qNj
Achtung
This tooltip is visible by default because it has "is_expanded" class. Philippe Model laceup sneakers White Outlet In China Cheap New Styles Outlet Official Clearance 100% Original 5eQAZMD
Fast Delivery Cheap Price UNNATURE TIME Casual laceups noir Footlocker Finishline Ec3iuyEc

Sie haben keine Produkte im Warenkorb.

VICIOUS CHZIP Classic ankle boots braun Clearance Outlet mYb3WLa

Les contenus ne sont pas tous disponibles dans la langue choisie. Désirez-vous découvrir le monde de la Rhätische Bahn dans son ensemble? anglais

Achtung
This tooltip is visible by default because it has "is_expanded" class. and this is a link
Achtung
This tooltip is visible by default because it has "is_expanded" class. and this is a link
Close Navigation
fr Account Search Menu

Les contenus ne sont pas tous disponibles dans la langue choisie. Désirez-vous découvrir le monde de la Rhätische Bahn dans son ensemble? anglais

Darauf legen wir den Fokus

In einem ersten Schritt legt die Rhätische Bahn den Fokus auf die zwei Handlungsfelder «Betriebliches Gesundheitsmanagement» und «Energiesparen». Dadurch soll die Gesundheit der Mitarbeitenden gestärkt sowie die Energieeffizienz gesteigert werden. Projekte und Kampagnen in diesen beiden Handlungsfeldern werden gezielt gefördert und begleitet. Die Entwicklung der übrigen Handlungsfelder wird überwacht, um bei Veränderungen rasch reagieren zu können.

Handlungsfelder der Rhätischen Bahn mit den zwei Fokusthemen «Energiesparen» und «Betriebliches Gesundheitsmanagement».

Im Bereich Energie kann die Rhätische Bahn den grössten Effekt erzielen, da der Energiebedarf sehr gross ist und aufgrund der zunehmenden Zugkilometer sowie der Ausstattung der Züge weiter steigt. Die Energieeffizienz zu steigern ist Teil der Strategie 2020. Massnahmen wie die Automatisierung der Weichenheizungen, die Optimierung von Gebäudeheizungen oder Energiesparmassnahmen an Fahrzeugen sollen dazu führen, dass der gesamte Energiebedarf der Rhätischen Bahn trotz zunehmenden Zugskilometern und höheren Komfortausrüstungen in den Zügen unterproportional ansteigt. Nebst der Steigerung der Energieeffizienz steht die Nutzung erneuerbarer Energie im Vordergrund. Dementsprechend bezieht die Rhätische Bahn den gesamten Strom für ihre Immobilien sowie die elektrisch betriebenen Triebfahrzeuge vollständig aus Wasserkraft.

Die Rhätische Bahn will die Gesundheit der Mitarbeitenden erhalten und stärken. Gesundheit ist nicht nur für jeden einzelnen Mitarbeitenden wichtig. Sie bildet zusammen mit anderen Faktoren auch die Grundlage für die Qualität der Arbeit und damit für den Erfolg des Unternehmens. Um alle gesundheitsrelevanten Aktivitäten, Strukturen und Prozesse zu koordinieren, wurden diese im «Betrieblichen Gesundheitsmanagement (BGM)» zusammengefasst. Arbeitssicherheit und der Eingliederungsprozess von verunfallten oder erkrankten Mitarbeitenden sind ebenso Bestandteile des BGM wie die Betriebliche Gesundheitsförderung.

Cela pourrait aussi vous intéresser

Kennzahlen

Find out more

Skip to Main Content

Home

Events

Community

Multimedia

Portals

Special Editions

Research Journals

Reviews Journals:Trends In...

Partner Journals

Information

Marketplace Recommendations
Cancer Immunotherapy Strategies Poster
Request a Cancer Immunotherapy Strategies Poster for your lab. – Bio-Techne
Adoptive Cell Transfer Research
Find products to analyze CAR signaling, expand cells, verify T-cell function, and more.
MAPK Signaling Pathway
A group of serine/threonine kinases that mediate intracellular signaling. Learn more. – Biorbyt
Plant Tissue Culture Products
Explore our non-animal culture products. Antibiotics, gelling agents, cytokinins and more.
Ads Powered with

Access provided by

< Previous Article
Buy Cheap Exclusive Free Shipping Manchester Great Sale Sperry Sojourn 2 Eye Molded Jersey Many Kinds Of Cheap Price Cheap Sale Store ZnYVj5n
Volume 19, Issue 13 , p1123–1127, 14 July 2009
Report
2018 Sale Online Salvatore Ferragamo Mens Cube Leather amp; Nubuck Sneakers Shop For For Sale 2018 Unisex Cheap Online For Sale Cheap Online Outlet Wide Range Of yDThOO
ALDERSHOT Casual laceups navy In China Online Best Prices Cheap Authentic Affordable Sale Online j9kHW
Emma Louise Stone
Search for articles by this author

Affiliations

Correspondence

Emma Louise Stone
Search for articles by this author

Affiliations

Correspondence

Gareth Jones
Search for articles by this author

Affiliations

Correspondence

Gareth Jones
Search for articles by this author

Affiliations

Correspondence

Stephen Harris
Search for articles by this author

Affiliations

Published Online: June 18, 2009
Published online: June 18, 2009
Captures
Mentions
Social Media
Citations
DOI: Wholesale Churchs Patent leather Pembrey loafers 2018 Unisex Cheap Price Cheap Extremely Outlet Locations Cheap Online Pay With Paypal Cheap Price mU0Fhn
Publication History
Published online: June 18, 2009 Accepted: May 8, 2009 ; Received in revised form: May 5, 2009 ; Received: April 6, 2009 ;
User License
TERREBONNE OUTDRY EXTREME Hiking shoes black/white Looking For Cheap Price Cheap Online Store Free Shipping Many Kinds Of Cheap 100% Original Popular For Sale CvXQOGaR

miR-122 levels are decreased in mice and patients with HH. () qPCR analysis of miR-122 expression in liver total RNA of WT ( = 8) and ( = 11) mice ( = 0.039). mmu-miR-122, miR-122 stem-loop. () Analysis of miR-122 expression in the liver of WT mice injected with dextran (Dxt; = 5) and iron-dextran (Fe; = 6) ( = 0.187) and () WT mice on a regular ( = 4) or iron-supplemented diet (dFe; = 4) ( = 0.471). () miR-122 levels were reduced in liver biopsies of HH patients ( = 6) compared with the control group without iron overload (Ctr; = 4) ( = 0.068). hsa-miR-122, miR-122 stem-loop. Data were normalized to the appropriate reference genes: miR-194 ( and ), mouse RNU6 (), and human RNU6 (). Data are mean ± SD, and values from WT mouse (–) and control patient () groups were set to 100%. * < 0.05, 2-tailed Student’s test.

Efficient and specific antagonism of miR-122 in murine liver. To functionally investigate a possible link between miR-122 and iron metabolism, we inhibited miR-122 by a single i.p. injection of locked nucleic acid–modified (LNA-modified) anti-miR oligonucleotides ( Original Grand Wing II Suede Sneakers Cheap Cost uAaTTItAZ
) into age- and sex-matched C57BL/6 WT mice. To inhibit miR-122 specifically, we injected an anti-miR compound with perfect complementarity to miR-122 (perfect match; referred to herein as PM_anti–miR-122). As negative controls, mice were injected either with an LNA control compound with 2 mismatches (referred to herein as 2MM_antimiR-122) or saline vehicle control (0.9% NaCl). Mice were sacrificed 3 and 6 weeks after injection. Independent of treatment, mice were viable and exhibited no overt physical or behavioral abnormalities. To assess the efficiency of miR-122 inhibition, hepatic miR-122 levels were measured by qPCR (Figure Super Specials RAINEL EVO Smart laceups brown/blue Sale Pay With Paypal Clearance Low Price Fee Shipping Official For Sale UD7vDL
A). The amount of detectable miR-122 was reduced compared with saline-injected mice by 28- and 11-fold at 3 and 6 weeks, respectively, after injection with PM_anti–miR-122. Injection of the 2MM_anti–miR-122 control did not significantly reduce miR-122 detectability. Expression of the miR-122 primary transcript was not altered under the experimental conditions (Supplemental Figure 1A). To exclude that PM_anti–miR-122 administration disturbs the expression of other miRNAs we analyzed miRNA expression profiles in the livers, hearts and spleens of the same mice (Supplemental Figure 2). Our data show specific and exclusive inhibition of miR-122 in the liver of PM_anti–miR-122 treated mice. In the spleen, expression of 3 miRNAs was increased in PM_anti–miR-122–treated mice, which may be a consequence of increased extramedullary hematopoiesis (see below). Alteration of the miRNA profile was not detected in the heart, where miR-122 is not expressed ( 26 ).

Figure 2

miR-122 depletion is functional. () miR-122 detectability was decreased in the liver of PM_anti–miR-122–injected mice. Mice were injected i.p. with a single dose of 25 μg/g PM_anti–miR-122 (PM), 2MM_anti–miR-122 (2MM), or saline (SAL) and sacrificed 3 or 6 weeks after injection. Hepatic miR-122 expression was analyzed by qPCR, and data were normalized to the expression of small nucleolar RNA Sno135. Detectability of miR-122 was reduced 3 ( = 0.0001) and 6 ( = 0.0001) weeks after PM_anti–miR-122 administration. () was increased in the liver of PM_anti–miR-122–injected mice 3 ( = 0.0001) and 6 ( = 0.0001) weeks after treatment. Values were normalized to mRNA expression of reference gene . Data are mean ± SD ( = 8), and the saline-treated group was set to 100%. ** < 0.01, 1-way ANOVA.

Furthermore, miR-122 inhibition by PM_anti–miR-122 increased hepatic mRNA levels of the miR-122 target gene aldolase A ( Aldoa ; ref. 31 ) at both 3 weeks (2.8-fold vs. saline; 4.0-fold vs. 2MM_anti–miR-122) and 6 weeks after treatment (3.4-fold vs. saline; 2.7-fold vs. 2MM_anti–miR-122; Figure 2 B). Likewise, serum cholesterol levels were decreased ( Free Shipping Visa Payment Good Selling Arcteryx Veilance Norvan Ld Shoes Red Beach New Arrival Cheap Online Clearance Outlet HapFP6nOa
, 31 ) 3 weeks after injection of PM_anti–miR-122 (Supplemental Figure 1B). Taken together, these data suggest that PM_anti–miR-122 injection specifically and efficiently antagonizes miR-122 and that miR-122 inhibition is functional.

Be the first to save!

Privacy Policy
Stay Connected
Mobile apps
Salvatore Ferragamo Mens CrocTextured Leather Loafer Free Shipping Huge Surprise OPEnv9
Outlet Find Great Pre Order Philippe Model Paris sneakers White Perfect Big Sale Cheap Price oR96t
Discount For Nice Store Sale Merrell Barkley Moc Castlerock Mens Slip on Shoes 2018 New Cheap Online Supply Vtqc14Bbx3
Barneys New York Mens Washed Leather Penny Loafers Explore Cheap Price 9zRD4N
© Wal-Mart Stores, Inc.
Ref: To ensure we are able to help you as best we can, please include your reference number: BPT5HIXSU5