P448 Mixed Runner Shoes White Cork Buy Cheap 2018 Newest Big Discount Sale Online y8SybuL24i

SKU10689500
P448 Mixed Runner Shoes - White Cork Buy Cheap 2018 Newest Big Discount Sale Online y8SybuL24i
P448 Mixed Runner Shoes - White Cork
The Standard
Login
Burberry Black Leather Sandals Buy Cheap Sale 7QLG9ZaKxx
Achtung
This tooltip is visible by default because it has "is_expanded" class. BOSS Hugo Boss Lowtop sneakers in Italian leather 10 Black Discount Manchester Great Sale Buy Cheap Store 4Ce10fdKk
Achtung
This tooltip is visible by default because it has "is_expanded" class. and this is a link
Close Navigation

Sie haben keine Produkte im Warenkorb.

Close Navigation

Les contenus ne sont pas tous disponibles dans la langue choisie. Désirez-vous découvrir le monde de la Rhätische Bahn dans son ensemble? Classic For Sale Cheap Prices Reliable Frenz LaceUp Leather Sneakers mBJ7BxxD

Achtung
This tooltip is visible by default because it has "is_expanded" class. and this is a link
Achtung
This tooltip is visible by default because it has "is_expanded" class. and this is a link
Close Navigation
GRANDSTAND II Trainers black/white/neutral grey Discount Get To Buy Clearance Amazing Price New Styles Sale Online NuZ4cX
Free Shipping Cheap Rick Owens Boat sneakers White Sale Pictures Best Deals ab6Kh
ECCO Helsinki Plain Toe Low Price Fee Shipping Sale Online Footlocker Pictures Sale Online Perfect Cheap Online Sale Order Sale Enjoy XUlIHqZM
Menu

Les contenus ne sont pas tous disponibles dans la langue choisie. Désirez-vous découvrir le monde de la Rhätische Bahn dans son ensemble? ALDO Ellmore Buy Cheap Cheap lSDJDw0IcA

Darauf legen wir den Fokus

In einem ersten Schritt legt die Rhätische Bahn den Fokus auf die zwei Handlungsfelder «Betriebliches Gesundheitsmanagement» und «Energiesparen». Dadurch soll die Gesundheit der Mitarbeitenden gestärkt sowie die Energieeffizienz gesteigert werden. Projekte und Kampagnen in diesen beiden Handlungsfeldern werden gezielt gefördert und begleitet. Die Entwicklung der übrigen Handlungsfelder wird überwacht, um bei Veränderungen rasch reagieren zu können.

Handlungsfelder der Rhätischen Bahn mit den zwei Fokusthemen «Energiesparen» und «Betriebliches Gesundheitsmanagement».

Im Bereich Energie kann die Rhätische Bahn den grössten Effekt erzielen, da der Energiebedarf sehr gross ist und aufgrund der zunehmenden Zugkilometer sowie der Ausstattung der Züge weiter steigt. Die Energieeffizienz zu steigern ist Teil der Strategie 2020. Massnahmen wie die Automatisierung der Weichenheizungen, die Optimierung von Gebäudeheizungen oder Energiesparmassnahmen an Fahrzeugen sollen dazu führen, dass der gesamte Energiebedarf der Rhätischen Bahn trotz zunehmenden Zugskilometern und höheren Komfortausrüstungen in den Zügen unterproportional ansteigt. Nebst der Steigerung der Energieeffizienz steht die Nutzung erneuerbarer Energie im Vordergrund. Dementsprechend bezieht die Rhätische Bahn den gesamten Strom für ihre Immobilien sowie die elektrisch betriebenen Triebfahrzeuge vollständig aus Wasserkraft.

Die Rhätische Bahn will die Gesundheit der Mitarbeitenden erhalten und stärken. Gesundheit ist nicht nur für jeden einzelnen Mitarbeitenden wichtig. Sie bildet zusammen mit anderen Faktoren auch die Grundlage für die Qualität der Arbeit und damit für den Erfolg des Unternehmens. Um alle gesundheitsrelevanten Aktivitäten, Strukturen und Prozesse zu koordinieren, wurden diese im «Betrieblichen Gesundheitsmanagement (BGM)» zusammengefasst. Arbeitssicherheit und der Eingliederungsprozess von verunfallten oder erkrankten Mitarbeitenden sind ebenso Bestandteile des BGM wie die Betriebliche Gesundheitsförderung.

Cela pourrait aussi vous intéresser

Kennzahlen

Find out more

Timberland Davis Square Plain Toe Chukka Wheat Nubuck Mens Lace up casual Shoes Cheap 100% Guaranteed d5Gv7v

Home

Events

Community

Multimedia

Portals

Special Editions

Research Journals

Reviews Journals:Trends In...

Partner Journals

Information

Marketplace Recommendations
Cancer Immunotherapy Strategies Poster
Request a Cancer Immunotherapy Strategies Poster for your lab. – Bio-Techne
Adoptive Cell Transfer Research
Find products to analyze CAR signaling, expand cells, verify T-cell function, and more.
MAPK Signaling Pathway
A group of serine/threonine kinases that mediate intracellular signaling. Learn more. – Biorbyt
Plant Tissue Culture Products
Explore our non-animal culture products. Antibiotics, gelling agents, cytokinins and more.
Ads Powered with

Access provided by

< Previous Article
Next Article >
Volume 19, Issue 13 , p1123–1127, 14 July 2009
Report
Officine Creative Lace Up Shoes for Men Oxfords Derbies and Brogues On Sale Black Leather 2017 8 Outlet Find Great Free Shipping Geniue Stockist Visit Cheap Price Pictures Sale Online lbrWr1wZ
Converse Plush Suede Oxford Sneaker Marketable Online Find Great Sale Online Cheap Shop Offer WZbYXY
Emma Louise Stone
ASICS Kanmei Mx Running Shoe Pick A Best Sale Online Free Shipping Wide Range Of Outlet Wiki Order cD1QG37WW

Affiliations

Correspondence

Emma Louise Stone
CLASSIC NYLON SG Trainers black/chalk Sale Visit Cheap Sale The Cheapest All Size Clearance Store Sale Online Cheap Sale Looking For 6EiLf

Affiliations

Correspondence

Gareth Jones
Columbia DORADO SLIP PFG 726 115 Discount Perfect BMSGm

Affiliations

Correspondence

Gareth Jones
Search for articles by this author

Affiliations

Correspondence

Stephen Harris
Search for articles by this author

Affiliations

Published Online: June 18, 2009
Published online: June 18, 2009
Captures
Mentions
Social Media
Citations
DOI: https://doi.org/10.1016/j.cub.2009.05.058
Publication History
Published online: June 18, 2009 Accepted: May 8, 2009 ; Received in revised form: May 5, 2009 ; Received: April 6, 2009 ;
User License
Figure 1

miR-122 levels are decreased in mice and patients with HH. () qPCR analysis of miR-122 expression in liver total RNA of WT ( = 8) and ( = 11) mice ( = 0.039). mmu-miR-122, miR-122 stem-loop. () Analysis of miR-122 expression in the liver of WT mice injected with dextran (Dxt; = 5) and iron-dextran (Fe; = 6) ( = 0.187) and () WT mice on a regular ( = 4) or iron-supplemented diet (dFe; = 4) ( = 0.471). () miR-122 levels were reduced in liver biopsies of HH patients ( = 6) compared with the control group without iron overload (Ctr; = 4) ( = 0.068). hsa-miR-122, miR-122 stem-loop. Data were normalized to the appropriate reference genes: miR-194 ( and ), mouse RNU6 (), and human RNU6 (). Data are mean ± SD, and values from WT mouse (–) and control patient () groups were set to 100%. * < 0.05, 2-tailed Student’s test.

Efficient and specific antagonism of miR-122 in murine liver. To functionally investigate a possible link between miR-122 and iron metabolism, we inhibited miR-122 by a single i.p. injection of locked nucleic acid–modified (LNA-modified) anti-miR oligonucleotides ( 31 ) into age- and sex-matched C57BL/6 WT mice. To inhibit miR-122 specifically, we injected an anti-miR compound with perfect complementarity to miR-122 (perfect match; referred to herein as PM_anti–miR-122). As negative controls, mice were injected either with an LNA control compound with 2 mismatches (referred to herein as 2MM_antimiR-122) or saline vehicle control (0.9% NaCl). Mice were sacrificed 3 and 6 weeks after injection. Independent of treatment, mice were viable and exhibited no overt physical or behavioral abnormalities. To assess the efficiency of miR-122 inhibition, hepatic miR-122 levels were measured by qPCR (Figure 2 A). The amount of detectable miR-122 was reduced compared with saline-injected mice by 28- and 11-fold at 3 and 6 weeks, respectively, after injection with PM_anti–miR-122. Injection of the 2MM_anti–miR-122 control did not significantly reduce miR-122 detectability. Expression of the miR-122 primary transcript was not altered under the experimental conditions (Supplemental Figure 1A). To exclude that PM_anti–miR-122 administration disturbs the expression of other miRNAs we analyzed miRNA expression profiles in the livers, hearts and spleens of the same mice (Supplemental Figure 2). Our data show specific and exclusive inhibition of miR-122 in the liver of PM_anti–miR-122 treated mice. In the spleen, expression of 3 miRNAs was increased in PM_anti–miR-122–treated mice, which may be a consequence of increased extramedullary hematopoiesis (see below). Alteration of the miRNA profile was not detected in the heart, where miR-122 is not expressed ( 26 ).

Brawns FOOTWEAR Ankle boots su YOOXCOM Geniue Stockist Cheap Price Outlet Websites Sale Online Store OVfqZ9ug

miR-122 depletion is functional. () miR-122 detectability was decreased in the liver of PM_anti–miR-122–injected mice. Mice were injected i.p. with a single dose of 25 μg/g PM_anti–miR-122 (PM), 2MM_anti–miR-122 (2MM), or saline (SAL) and sacrificed 3 or 6 weeks after injection. Hepatic miR-122 expression was analyzed by qPCR, and data were normalized to the expression of small nucleolar RNA Sno135. Detectability of miR-122 was reduced 3 ( = 0.0001) and 6 ( = 0.0001) weeks after PM_anti–miR-122 administration. () was increased in the liver of PM_anti–miR-122–injected mice 3 ( = 0.0001) and 6 ( = 0.0001) weeks after treatment. Values were normalized to mRNA expression of reference gene . Data are mean ± SD ( = 8), and the saline-treated group was set to 100%. ** < 0.01, 1-way ANOVA.

Furthermore, miR-122 inhibition by PM_anti–miR-122 increased hepatic mRNA levels of the miR-122 target gene aldolase A ( Aldoa ; ref. 31 ) at both 3 weeks (2.8-fold vs. saline; 4.0-fold vs. 2MM_anti–miR-122) and 6 weeks after treatment (3.4-fold vs. saline; 2.7-fold vs. 2MM_anti–miR-122; Figure 2 B). Likewise, serum cholesterol levels were decreased ( Cheap Discount Sale BARRON SHOE CASUAL Espadrilles haricot Fashion Style Cheap Price jA97I
, 31 ) 3 weeks after injection of PM_anti–miR-122 (Supplemental Figure 1B). Taken together, these data suggest that PM_anti–miR-122 injection specifically and efficiently antagonizes miR-122 and that miR-122 inhibition is functional.

Be the first to save!

Privacy Policy
Stay Connected
Mobile apps
MoneyCenter GH Bass amp; Co Larson Weejuns Red Hand Finished Full Grain Mens Shoes Prices rjdB0mnz
Vince Noble Dark Olive Mens Shoes From China Free Shipping Discount With Mastercard Cheap Affordable Free Shipping Discounts 7ZBxnC
Buy Cheap Best Seller Clearance View PHANTOMX 3 ACADEMY IC Indoor football boots white/chrome/volt Buy Online Cheap Price Good Selling Cheap Price UgoCQm7
© Wal-Mart Stores, Inc.
Ref: To ensure we are able to help you as best we can, please include your reference number: BPT5HIXSU5