Find Great For Sale Free Shipping Low Price Steve Madden PJourny Suede Chukka Boot Fashion Style Cheap Price ZQ1kPS

SKU14260779
Find Great For Sale Free Shipping Low Price Steve Madden P-Journy Suede Chukka Boot Fashion Style Cheap Price ZQ1kPS
Steve Madden P-Journy Suede Chukka Boot
John Varvatos WAXED NUBUCK LEATHER HIGH TOP SNEAKERS 100% Guaranteed Sale Online Buy Cheap Fake Z1FH2avbqi
adidas Cloudfoam Swift Racer Best Store To Get Cheap Price jb5bM5kHg
Individual Order Form
Achtung
This tooltip is visible by default because it has "is_expanded" class. Alexander McQueen classic brogues Brown Discount Fast Delivery Recommend Online Deals Cheap Online Outlet Cheap Prices 7bHz6GC9
Achtung
This tooltip is visible by default because it has "is_expanded" class. Rockport ProWalker M7100 Sport White/Wheat Mens Shoes Clearance Cheap Price Outlet Professional 5xmAfe
Close Navigation

Sie haben keine Produkte im Warenkorb.

Close Navigation

Les contenus ne sont pas tous disponibles dans la langue choisie. Désirez-vous découvrir le monde de la Rhätische Bahn dans son ensemble? MAMBA RAGE Basketball shoes blue/black/blue gale Factory Outlet bfBKQq

Achtung
This tooltip is visible by default because it has "is_expanded" class. and this is a link
Achtung
This tooltip is visible by default because it has "is_expanded" class. and this is a link
Close Navigation
fr Account Search Clearance Official Hart Schaffner Marx Gilbert Wingtip Derby Browse Sale Online Genuine Cheap Price Sale 100% Authentic 0Mafhx

Les contenus ne sont pas tous disponibles dans la langue choisie. Désirez-vous découvrir le monde de la Rhätische Bahn dans son ensemble? anglais

Darauf legen wir den Fokus

In einem ersten Schritt legt die Rhätische Bahn den Fokus auf die zwei Handlungsfelder «Betriebliches Gesundheitsmanagement» und «Energiesparen». Dadurch soll die Gesundheit der Mitarbeitenden gestärkt sowie die Energieeffizienz gesteigert werden. Projekte und Kampagnen in diesen beiden Handlungsfeldern werden gezielt gefördert und begleitet. Die Entwicklung der übrigen Handlungsfelder wird überwacht, um bei Veränderungen rasch reagieren zu können.

Handlungsfelder der Rhätischen Bahn mit den zwei Fokusthemen «Energiesparen» und «Betriebliches Gesundheitsmanagement».

Im Bereich Energie kann die Rhätische Bahn den grössten Effekt erzielen, da der Energiebedarf sehr gross ist und aufgrund der zunehmenden Zugkilometer sowie der Ausstattung der Züge weiter steigt. Die Energieeffizienz zu steigern ist Teil der Strategie 2020. Massnahmen wie die Automatisierung der Weichenheizungen, die Optimierung von Gebäudeheizungen oder Energiesparmassnahmen an Fahrzeugen sollen dazu führen, dass der gesamte Energiebedarf der Rhätischen Bahn trotz zunehmenden Zugskilometern und höheren Komfortausrüstungen in den Zügen unterproportional ansteigt. Nebst der Steigerung der Energieeffizienz steht die Nutzung erneuerbarer Energie im Vordergrund. Dementsprechend bezieht die Rhätische Bahn den gesamten Strom für ihre Immobilien sowie die elektrisch betriebenen Triebfahrzeuge vollständig aus Wasserkraft.

Die Rhätische Bahn will die Gesundheit der Mitarbeitenden erhalten und stärken. Gesundheit ist nicht nur für jeden einzelnen Mitarbeitenden wichtig. Sie bildet zusammen mit anderen Faktoren auch die Grundlage für die Qualität der Arbeit und damit für den Erfolg des Unternehmens. Um alle gesundheitsrelevanten Aktivitäten, Strukturen und Prozesse zu koordinieren, wurden diese im «Betrieblichen Gesundheitsmanagement (BGM)» zusammengefasst. Arbeitssicherheit und der Eingliederungsprozess von verunfallten oder erkrankten Mitarbeitenden sind ebenso Bestandteile des BGM wie die Betriebliche Gesundheitsförderung.

Cela pourrait aussi vous intéresser

Kennzahlen

Find out more

Skip to Main Content

Home

Events

Community

Multimedia

Portals

Special Editions

Research Journals

Reviews Journals:Trends In...

Partner Journals

Information

Marketplace Recommendations
Cancer Immunotherapy Strategies Poster
Request a Cancer Immunotherapy Strategies Poster for your lab. – Bio-Techne
Adoptive Cell Transfer Research
Find products to analyze CAR signaling, expand cells, verify T-cell function, and more.
MAPK Signaling Pathway
A group of serine/threonine kinases that mediate intracellular signaling. Learn more. – Biorbyt
Plant Tissue Culture Products
Explore our non-animal culture products. Antibiotics, gelling agents, cytokinins and more.
Ads Powered with

Access provided by

< Previous Article
Official HighTop Platform Sneakers Cheap Factory Outlet Clearance Cheap DDZeG6T7
Tommy Hilfiger Seaside 2 Cut-Price Cheap Manchester Great Sale Sale Visit New Discounts Cheap Price Cheap 100% Authentic 6vcWmigs5
, p1123–1127, 14 July 2009
Report
Free Shipping For Sale Sale 2018 New MRL420 Trainers grey sy976n2FOR
Switch to Enhanced View
Emma Louise Stone
Visa Payment Online Free Shipping Buy Hogan panelled logo sneakers Blue Lowest Price For Sale Cheap Sale Outlet Locations Hot Sale Sale Online akdxZmx

Affiliations

Correspondence

Emma Louise Stone
Search for articles by this author

Affiliations

Correspondence

Gareth Jones
Sale Visit DBYD x YOOX FOOTWEAR Ankle boots su YOOXCOM Clearance Outlet New Styles EAEIDL

Affiliations

Correspondence

Gareth Jones
Search for articles by this author

Affiliations

Correspondence

Stephen Harris
Saint Laurent classic derby shoes Black Outlet 2018 New Discount Real MjoJu4gx

Affiliations

Published Online: June 18, 2009
Published online: June 18, 2009
Captures
Mentions
Social Media
Citations
DOI: https://doi.org/10.1016/j.cub.2009.05.058
Publication History
Published online: June 18, 2009 Accepted: May 8, 2009 ; Received in revised form: May 5, 2009 ; Received: April 6, 2009 ;
User License
Really Online Under Armour UA Charged 24/7 Low Shopping Online Release Dates For Sale Buy Cheap Official Online Shopping nJVG5kbAF

miR-122 levels are decreased in mice and patients with HH. () qPCR analysis of miR-122 expression in liver total RNA of WT ( = 8) and ( = 11) mice ( = 0.039). mmu-miR-122, miR-122 stem-loop. () Analysis of miR-122 expression in the liver of WT mice injected with dextran (Dxt; = 5) and iron-dextran (Fe; = 6) ( = 0.187) and () WT mice on a regular ( = 4) or iron-supplemented diet (dFe; = 4) ( = 0.471). () miR-122 levels were reduced in liver biopsies of HH patients ( = 6) compared with the control group without iron overload (Ctr; = 4) ( = 0.068). hsa-miR-122, miR-122 stem-loop. Data were normalized to the appropriate reference genes: miR-194 ( and ), mouse RNU6 (), and human RNU6 (). Data are mean ± SD, and values from WT mouse (–) and control patient () groups were set to 100%. * < 0.05, 2-tailed Student’s test.

Efficient and specific antagonism of miR-122 in murine liver. To functionally investigate a possible link between miR-122 and iron metabolism, we inhibited miR-122 by a single i.p. injection of locked nucleic acid–modified (LNA-modified) anti-miR oligonucleotides ( High Quality Sale Online Rag amp; Bone Spencer Chukka Boots Nutmeg Buy Cheap Best UnW42E
) into age- and sex-matched C57BL/6 WT mice. To inhibit miR-122 specifically, we injected an anti-miR compound with perfect complementarity to miR-122 (perfect match; referred to herein as PM_anti–miR-122). As negative controls, mice were injected either with an LNA control compound with 2 mismatches (referred to herein as 2MM_antimiR-122) or saline vehicle control (0.9% NaCl). Mice were sacrificed 3 and 6 weeks after injection. Independent of treatment, mice were viable and exhibited no overt physical or behavioral abnormalities. To assess the efficiency of miR-122 inhibition, hepatic miR-122 levels were measured by qPCR (Figure Diesel Magente Exposure I Leather in Black Explore Online Clearance In China New Style Marketable For Sale Many Kinds Of Cheap Online hISn0MJR1l
A). The amount of detectable miR-122 was reduced compared with saline-injected mice by 28- and 11-fold at 3 and 6 weeks, respectively, after injection with PM_anti–miR-122. Injection of the 2MM_anti–miR-122 control did not significantly reduce miR-122 detectability. Expression of the miR-122 primary transcript was not altered under the experimental conditions (Supplemental Figure 1A). To exclude that PM_anti–miR-122 administration disturbs the expression of other miRNAs we analyzed miRNA expression profiles in the livers, hearts and spleens of the same mice (Supplemental Figure 2). Our data show specific and exclusive inhibition of miR-122 in the liver of PM_anti–miR-122 treated mice. In the spleen, expression of 3 miRNAs was increased in PM_anti–miR-122–treated mice, which may be a consequence of increased extramedullary hematopoiesis (see below). Alteration of the miRNA profile was not detected in the heart, where miR-122 is not expressed ( 26 ).

Free Shipping Cheap Clearance Exclusive Sperry Decoy Boot Waxed Canvas Waterproof nNEU4G8zcK

miR-122 depletion is functional. () miR-122 detectability was decreased in the liver of PM_anti–miR-122–injected mice. Mice were injected i.p. with a single dose of 25 μg/g PM_anti–miR-122 (PM), 2MM_anti–miR-122 (2MM), or saline (SAL) and sacrificed 3 or 6 weeks after injection. Hepatic miR-122 expression was analyzed by qPCR, and data were normalized to the expression of small nucleolar RNA Sno135. Detectability of miR-122 was reduced 3 ( = 0.0001) and 6 ( = 0.0001) weeks after PM_anti–miR-122 administration. () was increased in the liver of PM_anti–miR-122–injected mice 3 ( = 0.0001) and 6 ( = 0.0001) weeks after treatment. Values were normalized to mRNA expression of reference gene . Data are mean ± SD ( = 8), and the saline-treated group was set to 100%. ** < 0.01, 1-way ANOVA.

Furthermore, miR-122 inhibition by PM_anti–miR-122 increased hepatic mRNA levels of the miR-122 target gene aldolase A ( Aldoa ; ref. 31 ) at both 3 weeks (2.8-fold vs. saline; 4.0-fold vs. 2MM_anti–miR-122) and 6 weeks after treatment (3.4-fold vs. saline; 2.7-fold vs. 2MM_anti–miR-122; Figure 2 B). Likewise, serum cholesterol levels were decreased ( 30 , 31 ) 3 weeks after injection of PM_anti–miR-122 (Supplemental Figure 1B). Taken together, these data suggest that PM_anti–miR-122 injection specifically and efficiently antagonizes miR-122 and that miR-122 inhibition is functional.

Be the first to save!

GRAFFIO Trainers red Discount Cheapest OgyvF
Stay Connected
Discount Countdown Package Reliable Sale Online Tods classic boat shoes Black Get Authentic Cheap Online Rf6WlC
Born Decker Unisex Cool 7YFntFhTgB
Privacy Security CA Privacy Rights Terms of Use
© Wal-Mart Stores, Inc.
Ref: To ensure we are able to help you as best we can, please include your reference number: BPT5HIXSU5